Protein synthesis by human uterine cervix in organ culture relationship to herpes simplex virus infection andcarcinoma of the cervix by Mary Elizabeth Cowan

Cover of: Protein synthesis by human uterine cervix in organ culture | Mary Elizabeth Cowan

Published by University of Birmingham in Birmingham .

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Thesis (Ph.D.) - University of Birmingham, Dept of Medical Microbiology.

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StatementMary Elizabeth Cowan.
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Open LibraryOL13826864M

Download Protein synthesis by human uterine cervix in organ culture

Long-term organ culture of human uterine endocervix. Schürch W, McDowell EM, Trump BF. Explants of human endocervix have been maintained in organ culture for 24 weeks.

The epithelium was viable for the entire duration of culture, as demonstrated by ultrastructural morphology and mitotic by: bolic responses to carcinogens ().

Organ culture has the advantage over cell culture in that stromal and epithelial architecture and the normal cellular relationships remain preserved. In this paper we present results of long-term organ culture of the human uterine endocervix. The endo-cervical epithelium was maintained in culture for Cited by:   Glycoproteins from normal and malignant human cervix were studied using an organ culture system and compared by gel electrophoresis and autoradiograph Cited by: 5.

portion meets with the muscular body of the uterus at the internal cervical os. The portion of the cervix lying exterior to the external os is called the ectocervix.

This is the portion of the cervix that is • The cervix, the lower fibromuscular portion of the uterus, measures cm in length and cm. PROSTAGLANDINS THE REGULATORY INFLUENCE OF PROSTAGLANDINS ON PROTEIN SYNTHESIS IN THE HUMAN NON PREGNANT CERVIX A.

Norstr, L. Wilhelmsson and L. Hamberger Department of Obstetrics and Gynecology, University of Geborg, S 45 Geborg, Sweden. ABSTRACT Cervical connective tissue was obtained from non pregnant fertile women undergoing Cited by: Abstract.

Although the cervix was recognized as an organ entity as early as B.C. during the third Egyptian Dynasty, it was Soranus, in the first century A.D., who gave the first accurate description of the cervix uteri as a separate portion of the uterus. 48 The cervix (term taken from the Latin, meaning “neck”) is the most inferior portion of the uterus protruding into the upper vagina.

Abstract. The human cervix can today be considered as a separate functional entity within the uterus in comparison with an earlier widespread opinion that this structure merely played a passive role secondarily to contractions of the uterine body.

The cervix is a tubular pathway between the vagina and the uterine body, measuring around 2–3 centimeters in length. The cervix produces mucus, which changes during the menstrual cycle to act as a barrier or a transport medium to sperms dependent on the viscosity of the mucus.

Cervix, uterine. The cervix measures around 2–3 centimeters in length. It is part of the female reproductive system situated between the vagina and the uterine body.

The cervix is composed of fibrous, muscular and elastic tissue lined with columnar and squamous epithelium. bor, the numbers of nerve fibers and levels of neurotrophins and TRPV1 in the human cervix are considerably higher than in the corpus. These findings lend support to our hypothesis that the cervix uteri is the major site from which labor pain emanates.

Further-more, the sensory corpuscles identified in the non-distended corpus and cervix. The uterine cervix is a hormonally responsive organ whose function is tightly regulated during pregnancy.

Interstitial collagenase is believed to play a key role in the mechanism of cervical. Human Organ Systems. An organ system is a group of organs that work together to perform major functions or meet physiological needs of the body.

Figure below shows the eleven distinct organ systems in the human body. Assigning organs to organ systems can be imprecise since organs that “belong” to one system can also have functions integral to another system. Human reproductive system - Human reproductive system - The uterus: The uterus, or womb, is shaped like an inverted pear.

It is a hollow, muscular organ with thick walls, and it has a glandular lining called the endometrium. In an adult the uterus is cm (3 inches) long, 5 cm (2 inches) in width, and cm (1 inch) thick, but it enlarges to four to five times this size in pregnancy.

Search in book: Search. Contents. Introduction; An Introduction to the Human Body. Introduction; Overview of Anatomy and Physiology; Structural Organization of the Human Body; Functions of Human Life; Protein Synthesis; Cell Growth and Division; Cellular Differentiation; The. The uterine cervix produces a mucus that aids in carrying sperm from the vagina to the uterus, where it can fertilize an egg if the woman is ovulating.

Glycosylation is the most common and structurally diverse of all the post-translational modifications of proteins. Lipids and extracellular matrices are also often glycosylated. The mammalian uterus is highly enriched in glycoconjugates that are associated with the apical surfaces of epithelial cells and the secretions released by both epithelial and stromal cells.

When estradiol is administered to a mammal, the hormone becomes bound to uterine tissue, where it increases the rates of protein synthesis, of uptake of water and glucose, and, eventually, of growth of the lining epithelium and underlying muscular tissue (endometrium) of the uterus.

Female Reproductive Organs • The Female Reproductive organs comprise: • The Gonads- in the form of two ovaries • The accessory sex organs consisting of • The Fallopian Tube • Uterus • Cervix • Upper end of Vagina 3.

THE UTERUS The uterus is a pear-shaped muscular organ within the pelvis, located between the bladder and rectum. [Show full abstract] uterine cervix, in 20 cases of adenocarcinoma of the uterine cervix, in 29 cases of cervical intraepithelial neoplasia (CIN) and 16 cases of normal cervices.

Results. mTORC1 and its downstream S6K1 and CAD, ultimately enhancing DNA synthesis in the embryo and uterus.

Conclusions: Taken together, these studies demonstrate that CBS and MAT2A im-prove methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during. Physiology of the Uterus and Cervix Eric J.

Bieber The uterus, and specifically the endometrium, is a dynamic and ever-changing organ throughout much of a woman's life. The fundamental physiologic processes that occur from menarche to menopause must be well understood by physicians to allow appropriate diagnosis and treatment of underlying disorders.

The endocrine system regulates the growth of the human body, protein synthesis, and cellular replication. A major hormone involved in this process is growth hormone (GH), also called somatotropin—a protein hormone produced and secreted by the anterior pituitary gland.

Its primary function is anabolic; it promotes protein synthesis and tissue. The association between cervical cancer and human papillomavirus (HPV) is well known, but its association with human immunodeficiency virus (HIV) is controversial. Coinfection with HPV and HIV is to be expected and recent epidemiological data from Africa show that cervical cancer is the most common AIDS defining neoplasm in women.

Unlike other AIDS defining neoplasms, the occurrence of. Carcinoma, cervix - gross Carcinoma, cervix involving the vagina Carcinoma, cervix infiltrating the uterine corpus LSIL H & E ISH for HPV DNA Ki67 p16INK4 IHC Clinical course: Asymptomatic, Irregular vaginal bleeding or bleeding on touch, Leukorrhea, Dysuria; The endocrine system regulates the growth of the human body, protein synthesis, and cellular replication.

A major hormone involved in this process is growth hormone (GH), also called somatotropin—a protein hormone produced and secreted by the anterior pituitary gland. Figure (a) Most light microscopes in a college biology lab can magnify cells up to approximately times and have a resolution of about nanometers.

(b) Electron microscopes provide a much higher magnification, ,x, and a have a resolution of 50 picometers. (credit a: modification of work by "GcG"/Wikimedia Commons; credit b: modification of work by Evan Bench). Relaxin also helps dilate the cervix during labor. The placenta takes over the synthesis and secretion of progesterone throughout pregnancy as the corpus luteum degenerates.

Like estrogen, progesterone suppresses FSH and LH. It also inhibits uterine contractions, protecting the fetus from preterm birth. The uterus has three regions: the fundus, the body, and the cervix. It has three layers: the outer perimetrium, the muscular myometrium, and the inner endometrium.

The endometrium responds to estrogen released by the follicles during the menstrual cycle and grows thicker with an increase in blood vessels in preparation for pregnancy. On the protein: estrogen stimulate directly RNA synthesis lead to protein synthesis. progesterone it is production same as estrogen.

it has effect on smooth muscle leads to decrease muscle excitability leads to muscle relaxation mainly in uterus.

Thyroid function increase thyroid. Aims: Folate receptors (FRs) mediate cellular uptake of folates in many cancer cells and in folate deficiency heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) mediates translational upregulation of FR in cultured cervical cancer cells.

hnRNP-E1 can also interfere with human papillomavirus 16 (HPV) viral capsid protein synthesis (and thereby HPV proliferation) in vitro. Cell Culture. Culture Medium; Endothelial Progenitor Outgrowth Cells; Genomic DNA – Human Adult Normal Tissue: Uterus: Cervix, from a single donor.

Overview. BioChain’s Genomic DNAs are available from different human adult normal tissues. Each organ genomic DNA is from a single donor. Human papillomavirus (HPV) is a non-enveloped protein capsid containing eight genes in a circular, double-stranded DNA genome (Figure 1).

The genes are characterized as either early (E) or late (L) genes. The names are related to when the genes are expressed; e.g. early genes are produced early in the virus life cycle.

Human Anatomy & Physiology: Reproductive System; Ziser Lecture Notes, 14 decrease in testosterone can cause sterility 2. stimulates general protein synthesis 3.

promotes muscular development, bone growth, thickening of skin and growth of facial and body hair 4. development and maintenance of secondary sexual characteristics hair pattern. Human myometrial smooth muscle cell culture model. Human myometrial samples are obtained from lower uterine segment during elective Cesarean section of singleton pregnancies.

The samples are cleared of serosa, fibrous or damaged tissue. During pregnancy, the uterus enlarges and transforms into a muscular organ sufficient to accommodate the fetus, placenta, and amniotic fluid.

Uterine enlargement results from the stretching and hypertrophy of existing muscle cells and an accumulation of fibrous tissue, most of which is collagen, along with an increase in elastic tissue content. Reproductive System Powerpoint Lecture - Free download as Powerpoint Presentation .ppt /.pptx), PDF File .pdf), Text File .txt) or view presentation slides online.

A Powerpoint lecture covering both the male and female reproductive systems. Written for an introductory anatomy course. Estrogens, nucleic acids, and protein synthesis in uterine metabolism. Estrone interaction with the rat uterus: In vitro response and nuclear uptake.

Expression of cell CAM in the apical surface of rat uterine epithelium is controlled by ovarian steroid hormones.

The Fallopian tubes, uterus and cervix are made from human tissues obtained from women undergoing hysterectomies. The ovaries, however, are from mouse tissue, because healthy ovaries are rarely.

Uterus: this muscle-lined, triangular organ is where a fertilized egg implants and develops. This organ develops a thick blood lining and sheds this lining on a monthly cycle. Transport of eggs, sperm, and babies. Vagina: a highly expandable pouch structure that serves as the opening of the female reproductive tract to outside the body.

- excessive uterine bleeding - cancer of cervix, uterus or ovaries Partial (subtotal) Hysterectomy: body of uterus removed - cervix left in place Complete Hysterectomy: Removal of: body and cervix of uterus - uterine tubes - possibly ovaries - superior portion of vagina - pelvic lymph nodes - supporting structures such as ligaments.

Learn term:dna synthesis = always proceeds in 5' to 3' direction with free interactive flashcards. Choose from 17 different sets of term:dna synthesis = always proceeds in 5' to 3' direction flashcards on Quizlet.Argyrophil cells occur rarely in the normal human uterine cervix but are found in a variety of invasive tumors arising in the cervix.

Methods and Results: About normal human uterine cervices were stained with Grimelius argyrophilic reaction out of which cases (%) showed the positivity.The uterus (Figs., ) is a hollow, thick-walled, muscular organ situated deeply in the pelvic cavity between the bladder and its upper part the uterine tubes open, one on either side, while below, its cavity communicates with that of the vagina.

When the ova are discharged from the ovaries they are carried to the uterine cavity through the uterine tubes.

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